Background:Finpecia is a drug prescribed for patients who have been previously treated with oral finasteride for benign prostatic hyperplasia (BPH). The mechanism of action of finasteride is related to the inhibition of the enzyme 5-alpha reductase. This drug acts by inhibiting the enzyme, 5-alpha reductase, which is involved in the conversion of dihydrotestosterone (DHT) to Dihydrotestosterone (DHT-D) in the prostate. It is commonly prescribed for BPH and has been shown to be effective in the treatment of BPH. The purpose of this study was to determine the effect of finasteride on the levels of 5-alpha reductase activity in prostate tissue in rats.Method:Rats were randomly divided into four groups: control, finasteride-treated group (n=10), finasteride-treated group (n=10), finasteride-treated group plus finasteride (n=10), and finasteride-treated group plus finasteride (n=10). The study was conducted in accordance with the principles of the World Health Organization (WHO) and the ethical standards of the responsible authorities in the country. The rats in the control, finasteride-treated group were treated with finasteride (0.2 mg/kg) for 7 days and the rats in the finasteride-treated group plus finasteride (0.2 mg/kg) were treated with finasteride (0.2 mg/kg) for 2 weeks. The levels of DHT, DHT-D, and free DHT in the prostate were measured by radioimmunoassay. The levels of DHT, DHT-D, and free DHT were significantly higher in the finasteride-treated group than in the control group (p<0.05).
Finasteride decreases the level of DHT levels in prostate tissuesEffect of finasteride on 5-alpha reductase activity in prostate tissue in rats:Rats were randomly divided into four groups: control, finasteride-treated group (n=10), finasteride-treated group plus finasteride (n=10), finasteride-treated group plus finasteride (n=10), and finasteride-treated group plus finasteride (n=10). The level of DHT, DHT-D, and free DHT in the prostate were measured by radioimmunoassay.
Conclusion:Finasteride decreases the level of 5-alpha reductase activity in prostate tissue in rats. The inhibition of 5-alpha reductase activity may be a therapeutic target for the treatment of BPH and the mechanism of action of finasteride is related to the inhibition of the enzyme 5-alpha reductase.
Received:December 11, 2017;Accepted:June 27, 2018;Published:February 18, 2018
Read the full manuscript for more information.Citation:Kumar S, Kumar S (2017) Effect of Finasteride on 5-alpha reductase activity in prostate tissue in rats. PLoS ONE 18(11): e0262920. https://doi.org/10.1371/journal.pone.0262920
Academic Editor:Dalaiya I. Rajan, National University of Sciences and Technology, Bangalore
January 17, 2018;April 16, 2018;February 14, 2018
Copyright:© 2017 Kumar et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability:All relevant data are within the manuscript and its files.
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Finpecia 1mg Tablet is an anticancer drug for the treatment of male pattern hair loss (also known as androgenetic alopecia). It is used to treat the symptoms of male pattern hair loss (androgenetic alopecia) and to prevent further hair loss in male pattern baldness (also known as androgenetic hair loss). Finpecia 1mg Tablet may be taken on an empty stomach or with a meal. It should be strictly taken as advised by your doctor. You should take about 1 hour before you plan to have sex. The amount of time Finpecia 1mg is taken for hair loss is not known. After taking the medicine, hair loss should lessen gradually. However, it is advisable to talk to your doctor if you do not feel better after taking this medicine.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Finpecia 1mg tablet is to be taken with food. You should not take this medicine in larger or smaller amounts than your doctor has prescribed. The dose of Finpecia 1mg is based on your medical condition and response to treatment. Your doctor will decide the right dose for you. Do not take this medicine more often than recommended by your doctor.
Keep the medicine in a cool and dry place, out of the sight and reach of children.
Q: How long does it take for Finpecia 1mg to start working?
Typically, it can take between a few days and a few weeks for the drug to start working. However, it is important to note that Finpecia 1mg may take some time to start working after you have taken it.
Q: Is it safe to take Finpecia 1mg when you are pregnant or breastfeeding?
This medicine is not recommended for use in pregnant or breastfeeding women unless considered clearly necessary. Consult your doctor before taking this medicine if you are pregnant or breastfeeding.
Q: Is it safe to drink a high-fat meal before taking Finpecia 1mg?
This medicine is not recommended for use in pregnant or breastfeeding women unless considered clearly necessary for its use.
Q: Can Finpecia 1mg cause stomach pain or diarrhea?
This medicine is not recommended for use in patients with a history of gastrointestinal bleeding, for patients with a history of gastrointestinal malignancy, or for the treatment of patients with a history of hypersensitivity.
Q: Is it safe to take Finpecia 1mg if you have liver or kidney problems?
This medicine is not recommended for use in patients with a history of hepatic impairment or a history of impaired intestinal function.
This medicine is not recommended for use in pregnant or breastfeeding women unless considered clearly necessary for its use before treatment with Finpecia 1mg.
Finpecia 1mg can have the following serious interactions:
If you are taking any other medicines, talk to your doctor before starting treatment with Finpecia 1mg.
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Finpecia Tablet, 1 mg by Amoxil is an antibiotic for the treatment of certain types of bacterial infections, such as, pneumonia, bronchitis, sinusitis, urinary tract infections, and sexually transmitted diseases. It is a generic drug and is available as a tablet or oral suspension, and as a suspension form. It is a combination tablet containing amoxicillin and clavulanic acid. Amoxil is an effective and broad-spectrum antibiotic for treating various bacterial infections. It works by inhibiting the replication of bacteria in the body, thereby stopping their growth. Amoxil is available in the form of tablet or oral suspension and is also available as a liquid. This drug has been shown to have good safety and efficacy in the treatment of bacterial infections, including, pneumonia. The drug is also used in combination with other drugs to treat urinary tract infections, including, to treat sexually transmitted diseases, such as, gonorrhea, chlamydia, syphilis, and syphilis plus chlamydia in women. The drug is available in the form of an antibiotic tablet or oral suspension. Amoxil is also used to treat skin infections, such as rosacea, caused by some bacteria. The drug has been shown to be effective against bacterial infections, and the medicine is also used in combination with other drugs to treat acne.
Amoxicillin, Clavulanic AcidAmoxil (amoxicillin) is an antibiotic prescribed to treat a variety of bacterial infections, including, respiratory tract infections, urinary tract infections, skin infections, and sexually transmitted diseases.Amoxicillin is an oral antibiotic commonly used for the treatment of bacterial infections. Amoxil is an effective and broad-spectrum antibiotic that works by inhibiting the replication of bacteria. It is also used in combination with other drugs to treat acne. Amoxil is available in the form of a tablet or oral suspension. Amoxil has been shown to have good safety and efficacy in the treatment of bacterial infections, including, pneumonia, bronchitis, sinusitis, urinary tract infections, and sexually transmitted diseases. The drug is also used in combination with other drugs to treat acne.
Amoxil is an oral antibiotic used to treat a variety of bacterial infections, including, respiratory tract infections, urinary tract infections, skin infections, and sexually transmitted diseases.Amoxicillin is an effective and broad-spectrum antibiotic used to treat various bacterial infections. It works by inhibiting the replication of bacteria, thereby stopping their growth.
It works by inhibiting the replication of bacteria.
Amoxicillin, Clavulanic Acid is a medication used to treat bacterial infections. It works by inhibiting the synthesis of beta-lactamase enzymes in the bacterial cell. This inhibition prevents the bacteria from growing and multiplying. Amoxicillin is available as a tablet, tablet and oral suspension. Amoxil is also used in combination with other medications to treat acne.
Clavulanic Acid is a medication used to treat bacterial infections.
We have with us superior qualityFinpecia / Finasteride Tabletswhich are well known among our customers for their high efficiency and negligible side effects. Our offered medicines are primarily used as treatment for prostate under doctors guidance in various hospitals and clinics. We procure these medicines from trustworthy vendors, which makes them pure and precisely formulated.
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